PerfumersWorld BBA IFF KAO IFF TAKA Odour=> strong diffusive sweet floral musk powerful clean macrocylic musk Sweet and musky odor of good tenacity 156 comparable to that of many related products but much inferior to the tenacity of the modern macrocyclic Lactone type Musks. Its odor is described as a “clean”, sweet, floral, woody musk,[5] Research has shown that it is in particular the (4S,7R) and the (4S, 7S) forms of galaxolide that are the most powerful musk notes, with odor thresholds of 1 ng/l or less. Similar to Galaxolide but with added elegance, stronger and slightly “woodier” and a metalic undertone that replicates the smell of a hot iron running over a freshly cleaned t-shirt. Women’s Voices for the Earth commissioned a GreenScreen® for Safer Chemicals assessment of Galaxolide to determine its hazard level. The easiest way to stay tuned in to exciting events, breaking actions & updates on the issues you care about! 1031 33rd Street Contains=>. This Priority List was the 4th list compiled by the EU of high volume substances that were to be evaluated by the Member States’ Competent Authorities, as part of the requirements of EU Council regulation 793/93 “On the Evaluation and Control of the risk of existing substances”. The isomers are (4R,7R), (4R,7S), (4S,7S) and (4S, 7R). It is one of the musk components that perfume and cologne manufacturers use to add a musk odor to their products. 2016. and M. Wolf, Polycyclic musk fragrances in human adipose tissue and human milk. [2], Although there have been reports of galaxolide in environmental compartments,[11][12][13] these studies have been made part of galaxolide’s environmental safety reviews by various authorities, who have deemed that there is no need for risk reduction measures. One study found Galaxolide in 81% of water samples from Great Lakes tributaries that run through urban areas. Additionally the European Union Scientific Committee for Health and Environmental Risks (SCHER), an advisory body to the European Commission, independently reviewed the environmental, human health, and indirect exposure risk assessment, and agreed with all of the conclusions from the EU experts on the outcome that, "There is at present no need for further information and/or testing and no need for risk reduction measures". 11, pp: 3815-3820. (2016) Organic contaminants in Great Lakes tributaries: Prevalence and potential aquatic toxicity. Odour=> strong diffusive sweet floral musk powerful clean macrocylic musk Sweet and musky odor of good tenacity 156 comparable to that of many related products but much inferior to the tenacity of the modern macrocyclic Lactone type Musks 367-372. [19], Galaxolide is not an irritant, not toxic, not a CMR substance nor a sensitizer. 18, pp:5629-35. 41, No. [7][22][23], In 2002, The Scientific Committee on Cosmetics and Non-Food Products (SCCNFP), the expert scientific board that advises the European Commission on human health issues, reviewed the human safety of galaxolide, when used in cosmetic products, and issued a final opinion on 17 September 2002. Disinfectant chemicals called quaternary ammonium compounds “quats”, commonly found in wipes are especially problematic. [2] Baldwin AK, Corsi SR, DeCicco LA, Lenaker PL, Lutz MA, Sullivan DJ and Richards KD. This means that Galaxolide may interfere with hormones and other chemical signals in the body which can result in developmental, reproductive, metabolic, brain, and behavior problems. [2] Based on test data, the EU Scientific Committee for Consumer Safety included galaxolide in their proposal for extending the allergen information on cosmetic products as it claims to have seen only up to 100 individual cases worldwide in the last several decades who have reported irritation or allergic reactions to galaxolide through the use of cosmetic products. Environmental Science and Technology. Media inquiries? When household products containing Galaxolide are used, the long-lasting fragrance chemical ends up in wastewater, which survives wastewater treatment plants to end up in our waterways and eventually in the Great Lakes. [10], Galaxolide degrades in the environment to primary degradants with log Kow <4 and further to more hydrophilic products with Log Kow of <1. Galaxolide is a synthetic musk, a commonly used fragrance ingredient found in household products. (2009) Synthetic musks in blood of healthy young adults: Relationship to cosmetics use. [5] Luckenbach, T. et.al. [18], Galaxolide has been reported to be found in human biomonitoring studies and its presence in human tissue has been evaluated by several scientific authorities. Galaxolide is strong diffusive sweet floral musk clean macrocylic soap-powder macrocyclic lactone musks all-florals muguet laundry soap. What California’s Ban on Toxic Chemicals in Cosmetics Means for Salon Worker Health, Interview with Bria Gadsden of Love Your Menses, We Need to Talk About the Term ‘Feminine Hygiene’, Toxic exposure risks lurk in menstrual products, California Is About To Become the Second State Requiring Ingredient Transparency in Period Products, California lawmakers approve ingredient disclosure bill for menstrual products. A number of studies have detected Galaxolide contamination in the Great Lakes, in the water, air and sediment. 2007. [6], Galaxolide has a measured bioconcentration factor (BCF) in fish in a range of 600-1600 and a log octanol-water partition coefficient (Log Kow) of around 5.5 (5.3 – 5.9). 2009. End application data applies to experiments carried out by the authors or extrapolated from those experiments using computer algorithms. Its melting point is -20 °C and its boiling point is estimated to be 330 °C based on a boiling point of 160 °C at 4hPa. Galaxolide is slightly sweet and floral with a powdery, fresh, clean scent similar to opening a warm tumble dryer or hanging out clean bed sheets. Manufacturers still using Galaxolide simply must follow this lead. Galaxolide is widely used by cleaning and personal care product companies and can be found in many products including surface cleaners, laundry products, air fresheners, cosmetics and perfumes. (2005) Nitromusk and polycyclic musk compounds as long-term inhibitors of cellular xenobiotic defense systems mediated by multidrug transporters. Specifically, the GreenScreen® assigned the Benchmark 1 score due to Galaxolide’s high persistent, bioaccumulative and aquatic toxicity properties. Vol. Environmental Science and Technology. The outcome of all those studies is that galaxolide is safe for use in consumer products. Galaxolide (trade name; also known as Abbalide, Pearlide, Astrolide, Musk 50, Polarlide; chemical name 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8,-hexamethyl-cyclopenta[g]benzopyran or HHCB) is a synthetic muskwith a clean sweet musky floral woody odor used in fragrances. [2], Galaxolide was discovered at IFF in the 1960s, by Heering and Beets. Perfume-Uses=> All-types Florals Muguet Laundry Soap Musk Comfort And Softlan Up To 40% Tresor 20% Balsam Design 45% Woody-blends, All physical chemical data are derived from the galaxolide REACH registration dossier: Heeringa L.G. For examples, traces of galaxolide were detected in 97% of breast milk samples in mothers from Massachusetts in a 2004 study. Vol. Those participants that used scented lotions and perfumes had significantly higher levels of Galaxolide than those that did not. Galaxolide is the trade name from International Flavors & Fragrances Inc. (IFF) for the fragrance material with CAS Registry Number 1222-05-5 and CAS chemical name cyclopenta(g)-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-. [4], The GreenScreen® also noted a moderate human health hazard for endocrine disruption. A GreenScreen® takes into account data on 18 different health and environmental endpoints to determine a hazard score. Benchmark 1 is assigned to chemicals of highest concern whose use is recommended to be avoided. Galaxolide was first synthesized in 1965, and used in the late 1960s in some fabric softeners and detergents. January 2005. Vol.40, No. 554-555, 42-52. [4] Peck AM, Linebaugh EK, Hornbuckle KC. [2], Galaxolide is classified as R50/53 under the EU DSD and as H410 under EU CLP classification rules. 38, No.2, pp. Historic legislation was just signed into law in California that requires disclosure of ingredients used in institutional and household cleaning products. Galaxolide is a synthetic musk, a commonly used fragrance ingredient found in household products. Number 1. [15], 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[, InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3, InChI=1/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3, Except where otherwise noted, data are given for materials in their. Habanolide. At room temperature, it occurs as a highly viscous liquid. [1] High concentrations were also incorporated in fine fragrances. Denver, Colorado 80205, Phone: (406) 543-3747

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