system. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Unique fragment ions are observed with each occurring at a proline residue. PDF (10 MB), https://oaktrust.library.tamu.edu/bitstream/1969.1/ETD-TAMU-2012-08-11243/2/KMIEC-DISSERTATION.pdf, Update/Correction/Removal fragmentation of alkali-metal cationized peptides. Internal immonium ions are found to have the strongest intensity, whereas immonium ions arising from C-terminal residues are the weakest. Mass spectrometry techniques. This article is cited by Additionally, a home-built 193-nm photodissociation tandem time-of-flight mass Furthermore, b-type fragment ion formation is also favored at longer timescales for the arginine containing peptides investigated. the Altmetric Attention Score and how the score is calculated. The modifications result in improved mass range, signal-to-noise, and increased fragment ion collection efficiencies. redistribute this material, requesters must process their own requests via the RightsLink permission Get without permission from the American Chemical Society. You have to login with your ACS ID befor you can login with your Mendeley account. Request. Information about how to use the RightsLink permission system can be found at You are currently offline. http://pubs.acs.org/page/copyright/permissions.html. Find more information on the Altmetric Attention Score and how the score is calculated. However, their intensities may vary from one peptide to another. Fragmentation of an alkali metal-attached peptide probed by collision-induced dissociation fourier transform mass spectrometry and computational methodology. Peptide length and competition among residues also strongly influence the immonium ion production. To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Use of Ultraviolet Photodissociation Coupled with Ion Mobility Mass Spectrometry To Determine Structure and Sequence from Drift Time Selected Peptides and Proteins. The factors affecting peptide fragmentation have been extensively studied in the literature in order to better predict the fragment ion spectra of peptides and proteins. Department of Chemistry, Indiana University, 800 East Kirkwood Ave., 47405, Bloomington, IN, USA, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 339-701, Daejeon, South Korea, Institute for Basic Science (IBS), Center for Catalytic Hydrocarbon Functionalizations, 339-701, Daejeon, South Korea, Factors Affecting the Production of Aromatic Immonium Ions in MALDI 157 nm Photodissociation Studies. The fragmentation pattern of several proline containing peptides is examined by collision-induced dissociation and 193-nm photodissociation. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Few differences are detected between CID and 193-nm photodissociation spectra, indicating that the proline residues direct fragmentation rather than the dissociation method. On most graphs, the mass -- measured in atomic mass units (amu) -- is plotted on the x-axis. Some features of the site may not work correctly. While there are countless influences to consider, metal cation binding in the gas-phase is particularly interesting. (August 2012) Kevin Lee Kmiec, B.A., Hendrix College Chair of Advisory Committee: Dr. David H. Russell The factors affecting peptide fragmentation have been extensively studied in the literature in order to better predict the fragment ion spectra of peptides and proteins. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Additionally, a home-built 193-nm photodissociation tandem time-of-flight mass spectrometer is utilized to study how peptide fragmentation kinetics affect the fragmentation pattern observed. not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information Tandem Mass Spectrometry: Tandem Mass Spectrometry, usually referred to as MS/MS, involves the use of 2 or more mass analyzers. Mass spectrometry is a destructive method used to measure molecular weight and provide. Your Mendeley pairing has expired. Find more information about Crossref citation counts. Side chain specific sequence ions, Influence of Peptide Composition, Gas-Phase Basicity, and Chemical Modification on Fragmentation Efficiency: Evidence for the Mobile Proton Model, Cyclization reaction of peptide fragment ions during multistage collisionally activated decomposition: An inducement to lose internal amino-acid residues, The mechanism of C-terminal fragmentations in alkali metal ion complexes of peptides, Secondary Interactions Affecting the Dissociation Patterns of Arginine-Containing Peptide Ions, Investigation of gas phase ion structure for proline-containing b2 ion, The structure and fragmentation of Bn (n≥3) ions in peptide spectra. For permission to reproduce, republish and In a MALDI-TOF/TOF mass spectrometer, singly charged peptides photofragmented with 157 nm VUV light yield a copious abundance of immonium ions, especially those from aromatic residues. Factors Affecting the Fragmentation of Peptide Ions: Metal Cationization and Fragmentation Timescale. http://pubs.acs.org/page/copyright/permissions.html, https://doi.org/10.1021/acs.analchem.6b01705. Immonium ions are commonly observed in the high energy fragmentation of peptide ions. Using fragmentation patterns. Working out … 2 publications. Journal of the American Society for Mass Spectrometry. Relative intensity, which measures how many ions of a given mass are detected, is plotted on the y-axis. Herein…, Collision-induced fragmentation of (M + H)+ ions of peptides. Please reconnect. ... Further fragmentation of such a cation generally results in another even-electron cation and a.

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